LDAA therapy combines low-dose azathioprine with allopurinol to redirect toxic metabolite production toward therapeutic effects. It’s a proven solution for patients with high liver enzymes or poor response to standard thiopurine therapy, but requires strict monitoring to avoid bone marrow suppression.
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Azathioprine and Allopurinol: How Low-Dose Combination Therapy Prevents Toxic Metabolite Buildup
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